ChloroquineV1, Main, Exploration, bibRecord, 001914

Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda

Identifieur interne : 001914 ( Main/Exploration ); précédent : 001913; suivant : 001915

Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda

Auteurs : Helena Hildenwall [Suède] ; Jenny Lindkvist [Suède] ; James K. Tumwine [Ouganda] ; Yngve Bergqvist [Suède] ; George Pariyo [Ouganda] ; Göran Tomson [Suède] ; Stefan Peterson [Suède, Ouganda]

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2009.

RBID : Pascal:09-0076781

Descripteurs français

Pascal (Inist)
- Pneumonie, Paludisme, Antibactérien, Validité, Antipaludique, Antiparasitaire, Enfant, Antibiotique, Milieu urbain, Hôpital, Ouganda, Médecine tropicale, Forme grave.
Wicri :
- geographic : Ouganda.
- topic : Enfant, Antibiotique.

English descriptors

KwdEn :
- Antibacterial agent, Antibiotic, Antimalarial, Child, Hospital, Malaria, Parasiticide, Pneumonia, Tropical medicine, Uganda, Urban environment, Validity.

Abstract

Febrile children in low-income countries receive care from multiple sources, and caretakers' ability to report drug intake is crucial for appropriate prescription of drugs when reaching health facilities. This study describes and validates caretakers' reported use of sulfamethoxazole, chloroquine and sulfadoxine in their children. We performed a cross-sectional study in 139 children diagnosed with severe pneumonia at hospital in Kampala, Uganda. Caretakers were interviewed regarding treatments given prior to arrival at the hospital. Reported drug intake was compared to drug levels in blood sampled on filter paper, analyzed by HPLC methods. Caretakers under-reported intake of the studied drugs. Positive and negative predictive values were 67 and 64% for sulfamethoxazole, 69 and 52% for chloroquine and 85 and 62% for sulfadoxine. Many caretakers were unaware of what drug had been given to the child, and more so if treated outside the home (risk ratio 2.6, 95% Cl 1.2-5.6). We conclude that caretakers' reports of drug intake have limited validity. Health workers need to improve counseling of caretakers during drug dispensing, especially for antibiotics. The roles and names of different drugs should be emphasized during counseling, and existing information systems such as immunization cards should be considered for record-keeping of treatment given.

Affiliations:

Ouganda, Suède

Links toward previous steps (curation, corpus...)

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to stream PascalFrancis, to step Checkpoint: 000023
to stream Main, to step Merge: 001918
to stream Main, to step Curation: 001914

Le document en format XML

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<front><div type="abstract" xml:lang="en">Febrile children in low-income countries receive care from multiple sources, and caretakers' ability to report drug intake is crucial for appropriate prescription of drugs when reaching health facilities. This study describes and validates caretakers' reported use of sulfamethoxazole, chloroquine and sulfadoxine in their children. We performed a cross-sectional study in 139 children diagnosed with severe pneumonia at hospital in Kampala, Uganda. Caretakers were interviewed regarding treatments given prior to arrival at the hospital. Reported drug intake was compared to drug levels in blood sampled on filter paper, analyzed by HPLC methods. Caretakers under-reported intake of the studied drugs. Positive and negative predictive values were 67 and 64% for sulfamethoxazole, 69 and 52% for chloroquine and 85 and 62% for sulfadoxine. Many caretakers were unaware of what drug had been given to the child, and more so if treated outside the home (risk ratio 2.6, 95% Cl 1.2-5.6). We conclude that caretakers' reports of drug intake have limited validity. Health workers need to improve counseling of caretakers during drug dispensing, especially for antibiotics. The roles and names of different drugs should be emphasized during counseling, and existing information systems such as immunization cards should be considered for record-keeping of treatment given.</div>
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Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda

Low validity of caretakers' reports on use of selected antimalarials and antibiotics in children with severe pneumonia at an urban hospital in Uganda

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri